The rapid growth of cultural evolutionary science, its expansion into numerous fields, its use of diverse methods, and several conceptual problems have outpaced corollary developments in theory and philosophy of science. This has led to concern, exemplified in results from a recent survey conducted with members of the Cultural Evolution Society, that the field lacks ‘knowledge synthesis’, is poorly supported by ‘theory’, has an ambiguous relation to biological evolution and uses key terms (e.g. ‘culture’, ‘social learning’, ‘cumulative culture’) in ways (...) that hamper operationalization in models, experiments and field studies. Although numerous review papers in the field represent and categorize its empirical findings, the field's theoretical challenges receive less critical attention even though challenges of a theoretical or conceptual nature underlie most of the problems identified by Cultural Evolution Society members. Guided by the heterogeneous ‘grand challenges’ emergent in this survey, this paper restates those challenges and adopts an organizational style requisite to discussion of them. The paper's goal is to contribute to increasing conceptual clarity and theoretical discernment around the most pressing challenges facing the field of cultural evolutionary science. It will be of most interest to cultural evolutionary scientists, theoreticians, philosophers of science and interdisciplinary researchers. (shrink)

Reciprocal interactions between the host circadian clock and the microbiota are evidenced by recent literature. Interestingly, dysregulation of either the circadian clock or microbiota is associated with common human pathologies such as obesity, type 2 diabetes, or neurological disorders. However, it is unclear to what extent a perturbation of pathways regulated by both the circadian clock and microbiota is involved in the development of these disorders. It is speculated that these perturbations are associated with impaired growth hormone (GH) secretion and (...) sexual development. The GH axis is a broadly neglected pathway and could be the main converging point for the interaction of both circadian clock and microbiota. Here, the links between the circadian clock and microbiota are reviewed. Finally, the effects of chronodisruption and dysbiosis on physiology and pathology are discussed and it is speculated whether a common deregulation of the GH pathway could mediates those effects. (shrink)

Recent discussions of ontology have shown an interest in the relation between logic, language and ontology. Quine, for example, has shown how sentences translated into canonical form determine ontological commitment in terms of the values over which bound variables range, while Strawson has maintained that conditions inherent to language determine a system of ontological concepts. But in these discussions the role linguistics might have in the construction of ontological schemes is seldom seriously considered. Except for Benjamin Lee Whorf’s examination (...) through the use of descriptive linguistic techniques of the relation between ontological schemes and the structure of languages, little has been done to apply the results of linguistic research to questions of ontology. In the past this could be attributed to the absence in structural linguistics of significant generalizations about language above the morphophonemic level. This situation has altered with the development of transformational linguistic theory. That theory contains an extensive set of generalizations about the form and content of any natural language. (shrink)

Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

This issue is dedicated to consciousness in medieval and early modern philosophy of mind. It aims to shed new light on the continuities and innovations during the transition from medieval to early modern philosophy of mind. The four papers, by Sonja Schierbaum, Daniel Schmal, Oliver Istvan Toth, and Philipp N. Müller, focus on consciousness and, more specifically, on one of its less frequently considered aspects: memory.

En este texto se recoge la experiencia y el estudio realizado en el Grado de Educación Infantil del Centro Universitario Cardenal Cisneros (Madrid), ante la necesidad de mostrar a los estudiantes del 2º curso, matriculados en la asignatura “La Innovación Educativa” otra forma de aprender y enseñar, basándose en su propia experiencia. Pero para poder valorar esta experiencia, era necesario encontrar un modelo a seguir y desde el que recoger información, indagar sobre lo que ocurría en la propia aula y (...) ofrecer un proceso formativo e investigador flexible. Para ello se utilizó la metodología de la investigación-acción. (shrink)

Various theories on personal goal striving rely on the assumption that failure raises doubts about the goal. Yet, empirical evidence for an association between objective failure experiences and doubts about personal long-term goals is still missing. In a longitudinal field study, applicants for a job as a police trainee (n = 172, Mage = 25.15, 55 females and 117 males) were accompanied across three measurement times over a period of five months. We investigated the effects of failure and initial expectation (...) of success (in the standardized selection process) on doubts regarding the superordinate goal of becoming a police officer. As hypothesized, both failure and low initial expectation of success as well as their interaction led to increased goal-related doubts over time. The findings provide first empirical evidence for the role of failure in the emergence of goal-related doubts in personal long-term goals and, therefore, the disengagement process as it is hypothesized in various theories on goal striving and life-span development. (shrink)

Protein turnover (PT) has been formally defined only in equilibrium conditions, which is ill‐suited to quantify PT during dynamic processes that occur during embryogenesis or (extra) cellular signaling. In this Hypothesis, we propose a definition of PT in an out‐of‐equilibrium regime that allows the quantification of PT in virtually any biological context. We propose a simple mathematical and conceptual framework applicable to a broad range of available data, such as RNA sequencing coupled with pulsed‐SILAC datasets. We apply our framework to (...) a published dataset and show that stimulation of mouse dendritic cells with LPS leads to a proteome‐wide change in PT. This is the first quantification of PT out‐of‐equilibrium, paving the way for the analysis of biological systems in other contexts. (shrink)

Caring for hospitalized patients with COVID-19 raises ethical dilemmas in which clinicians must weigh the unknown value of an intervention against the unknown risk of viral transmission. Current guidelines for delivering high-value care in the time of the COVID-19 pandemic do not directly address ethical dilemmas that arise from the unique concerns of individual patients. We propose an “ethical pause” in which clinicians address ethical dilemmas by taking time to ask three questions that invoke the major bioethical principles of beneficence, (...) nonmaleficence, and distributive justice: will this intervention help my patient? Could this intervention harm my patient? Could this intervention harm or help others? Using two exemplar cases, we demonstrate how the process of deliberately asking and answering structured ethical questions is a mindful problem-solving strategy that facilitates delivery of high-value care. (shrink)

The author devotes a good number of pages to clarifying the relations between PHN, experimental psychology, and metaphysics. It is this thesis, a problem of the order of knowledge, that we wish to question. We shall first present some of the difficulties that give rise to the problem. Second, we shall indicate the kind of knowledge which PHN is. Third, we shall attempt to demonstrate that in the body of his work the kind of knowledge represented is that of the (...) "metaphysics of man" and not the "philosophy of human nature." Finally, we shall point out the importance, and non-verbal character, of a correct answer to the problem. (shrink)

Critically examining what most people take for granted is central to philosophical inquiry. Philosophers who accept positions on policy making commissions, tasks forces, or committees cannot, however, play the same uncompromisingly critical role in this capacity as they do in the classroom or in their personal research or writing. Still, philosophers have much to contribute to such bodies, and they can do so without compromising their integrity or betraying themselves as philosophers. Keywords: compromise, critical reflection, embryo research, integrity, organ transplantation, (...) policy development, Warnock Committee CiteULike Connotea Del.icio.us What's this? (shrink)

One finds throughout the history of philosophy repeated though apparently unsuccessful attempts to decide upon the nature or essence of language. This is not a trivial problem. When philosophers themselves have tried to resolve it they seem inevitably to postulate some nonovert level of linguistic form which is more basic to language than its overt grammatical forms. Now linguists have become involved in making similar claims. This is in large measure due to Noam Chomsky’s revolutionary work in transformational generative grammar, (...) research which has lead to a new conception of the goals and nature of linguistic theory. Whatever might be the ultimate fate of Chomsky’s own proposals concerning the nature of language, his insistence on descriptive precision and on theoretically sophisticated models in linguistics will remain paradigmatic. What is in fact most revolutionary about transformational linguistics is not the construction of precise and detailed grammars per se, but the parallel claim that there exist underlying realities of language which to a large extent dictate its overt form and content. For Chomsky these realities are part of the deep structure of language. Although other linguists do not share his view that there is an exclusively syntactically based deep structure, transformationalists generally do agree that there is some linguistic level underlying surface structure which accounts for it. Disagreement exists over the nature of this underlying reality, and it is on this issue that linguistics has a significant point of contact with philosophy. (shrink)

In this paper we discuss ‘sustainable management’ which is being advocated by some in the business community. It may be that a professed commitment to sustainable development is merely a way for contemporary businesses to continue with ‘business as usual’ behind its façade. We believe that if business practices are to change, then education must change to allow students to live the ‘good’ lives promoted both by early philosophers and now by those professing the merits of sustainable development. The sustainable (...) development paradigm, if adopted fully, may result in the best of business decisions being made; it may provide humankind with a way to avoid the self-destruction which has been threatening throughout the 20th Century. Sustainable management requires business decision makers to consider how their decisions will affect the social and natural environments as well as their organisations’ profitability. It encourages a moral approach to business decision making and requires managers to recognise that genuinely long-term decision criteria will ultimately benefit their businesses, their societies, the natural environment and humankind. Although sustainable management is promoted as a ‘new’ paradigm, we argue that its principles should have been promoted through our educational systems for many centuries; they have not been. (shrink)

Der Begriff der Autorität verortet sich im 20. Jahrhundert in einer komplexen Matrix zwischen zeitgeschichtlichem Problembewusstsein, »konservativem« Denken und politischer Theoriebildung. Drei Perspektiven kennzeichnen die Rede von Autorität im 20. Jahrhundert: erstens die vermeintliche Krise einer vormals fraglosen Gültigkeit, zweitens der Versuch genealogischer Rückversicherung durch Versatzstücke der Tradition und drittens die Behauptung, Autorität könne als Grundbegriff politischer Theoriebildung und insbesondere demokratischer Ordnungen dienen. Der Sammelband analysiert das Konzept der Autorität entsprechend entlang der drei Dimensionen der Krise, der Konstruktion und der (...) Konjunktur. Der Band arbeitet dabei interdisziplinär: Vereint werden historische, literaturwissenschaftliche und philosophische Ansätze. (shrink)